CANE EYE Supplement

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Ingredients and information​

https://blog.vetnaturals.com/top-5-benefits-of-inulin-for-dogs/

Inulin is an important and common component in many pet health supplements.  It functions to help canine absorption of the supplement.  

Inulin is a type of soluble fiber found in wheat, onion, bananas, garlic, and asparagus and is especially found in the chicory plant. It is a fructan that stores carbohydrates and is a prebiotic which feeds and encourages the growth and improves activity of beneficial organisms within your pet’s gastrointestinal tract.

It has also been found to decrease GI upset resulting in less diarrhea in pets.

Studies show us that it helps with Inflammatory bowel disease and possesses antioxidant properties which are helpful for the eyes..

We chose to include inulin for all these reasons and to improve our product’s taste.  It is a natural alternative to fats, sugars, or corn syrup that we did not wish to use.

  • Hall, Edward, and Alexander German. “Diseases of the Small Intestine.” Textbook of Veterinary Internal Medicine, Elsevier, 2017.
  • Shang, H et.al. In vitro and in vivo antioxidant activities of inulin. Public Library of Science. Jan 2018; 13 (2): e0192273.
  • Simpson, Kenneth W, and Albert E Jergens. “Pitfalls and Progress in the Diagnosis and Management of Canine Inflammatory Bowel Disease.” Veterinary Clinics of North America: Small Animal Practice, vol. 41, no. 2, 2011, pp. 381–398.
  • Wortinger, A. “What do Prebiotics and Probiotics Really Do? Southwest Veterinary Symposium. Veterinary Information Network, 2018.

https://pubmed.ncbi.nlm.nih.gov/12088533/

This is a plant in the wheat family which contains many nutrients including vitamins, amino acids, chlorophyll, fiber, and enzymes.

Wheat seedling powder has antioxidant activity which helps the ocular surface, and also aids breath freshening, body odor control, blood cleansing, digestion, constipation prevention, energy boosting and has antiseptic activity.

Wheatgrass also contains properties that have been shown in several studies to be an extremely effective anti-inflammatory agent.

https://pubmed.ncbi.nlm.nih.gov/22038065/            

Spirulina is a cyanobacterium known as Arthrospira platensis. It contains a blue pigment that allows the bacteria to produce its’ own food through photosynthesis.  Spirulina is a nutritional powerhouse that is composed of more than 50% protein and chlorophyll.  It’s a very dense composition of vitamins, minerals, amino acids, omega-3 fatty acids, enzymes, minerals, phytonutrients, and antioxidantsto protect your pup’s ocular surface.

We like it for our pets because it is a potent anti-inflammatory which helps dry eyes and increases immune support  to help fight bacterial and yeast overgrowth. It can provide more metabolic energy to revitalize your dog's metabolism and help him or her heal faster,

DHA is docosahexaenoic acid which is a type of omega-3 fatty acid that dogs cant manufacture but helps brain and central nervous system development and function.

In a 2021 review of 23 published studies of the effects of DHA on dogs and cats, the authors concluded that “a therapeutic benefit was found in canine allergic dermatitis, haircoat disorder, keratoconjuncitivis sicca (dry eye), valvular disease and canine and feline osteoarthritis.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193331/#:~:text=Taken%20together%2C%20adjuvant%20prescription%20of,sicca%20and%20canine%20valvular%20disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917524/

Astaxanthin is a powerful antioxidant found in red algae powder and is a compound called carotenoids.  These occur in nature with a red pigment and are powerful anti-inflammatories.  Another well known carotenoid (and ingredient in cane-eye) is beta carotene.

Antioxidants are an important nutrient to fight against free radical damage which can form when your dog is exposed to toxins such as pollution.chemicals. pesticides or highly processed foods. The associated inflammation can damage and reduce the volume of the aqueous portion of the tear film that is formed by your dog’s lacrimal gland leading to corneal dryness and irritation. This gland can be revitalized with the proper nutritional management.

One of the leading properties of astaxanthin is that it is one of the few anti-inflammatories that can can cross the blood brain barrier to reach the retina which can aid in retinal detachment and overall eyesight. Although there no studies that show this, it might even be effective in preventing cataracts.

In addition, astaxanthin has been found to help with joint health by reducing systemic inflammation and lower the C-reactive protein (CRP) in the body which is a key indicator of inflammatory diseases.

This is another potent antixoxidant which can be beneficial in fighting free radicals in the body and supporting the health of retinal cells.  This helps keep the retina functioning and supports healthy, sharp vision even in aging dogs.

https://onlinelibrary.wiley.com/doi/abs/10.1111/ceo.14207

The study above shows that the clinical efficacy of anthocyanin oligomers (grape seed extract) is an effective treatment for dry eyes.  The anthocyanin oligomers were safe and effective in mild to moderate dry eye disease by improving the tear break up time, maintaining normal intraocular pressure, sustaining the ocular surface, and reducing patient symptomatology.  “The use of oral anthocyanin oligomers in the treatment of dry eye patients can enhance the therapeutic effect and improve the quality of life of patients while ensuring the safety of treatment, making this therapeutic option suitable for wider application.”

It may even potentially reduce or slow the growth of cataracts.

https://iovs.arvojournals.org/article.aspx?articleid=2392389

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973095/

Vitamin C is needed for growth and repair of tissues in all parts of  the body. It helps the body make collagen, an important protein to make skin, cartilage, tendons, ligaments, and blood vessels. It is also needed for healing wounds, and for repairing and maintaining bones and teeth.

In the eye, it is present in the lens and the surrounding ocular tissues and humors and acts as a sort of sunscreen/block to protect the eye’s lens from UV induced oxidative damage.

https://pubmed.ncbi.nlm.nih.gov/15228513/

https://www.mdpi.com/2072-6643/12/4/952

Your dogs tear film contains vitamin C and this nutrient helps protect the eyes.  Research has proven that vitamin C helps improve tear production.

CoQ10 reduces oxidative stress, helping in ocular conditions like glaucoma, dry eyes, cataracts, and macular degeneration.  It also acts as a neuroprotective agent in glaucoma.

 Evidence on neuroprotective properties of coenzyme Q10 in the treatment of glaucoma. Neural Regen Res. 2019 Feb; 14(2): 197–200.

In addition, CoQ10 supports a healthy heart by enhancing blood flow, protecting blood vessels, and promoting proper heart function.  It can also protect the kidneys from damage and improving their function CoQ10 increases oxygen in your pet’s lung tissue and ease inflammation.  

https://www.askariel.com/CoQ10-for-Cats-and-Dogs-p/17.htm#:~:text=Dogs%20And%20Cats%20With%20Eye,eye%2C%20cataracts%20and%20macular%20degeneration.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034585/

https://pubmed.ncbi.nlm.nih.gov/28937867/

The above study shows that administration of CoQ10 causes a reduction in oxidative damage and protects the lacrimal glands ( which produce tears) both in histopathological and tissue cytokine level assessments. 

Vitamin E is an antioxidant which promotes cell membrane protection.  It has been found to benefit your dog’s skink coat, muscles, and vision/dry eyes.  

Vitamin E is composed of two forms of molecules, tocopherols and tocotrienols.  Tocopherols are the more commonly added to pet foods and supplements in the form of “mixed-tocopherols.”

An excellent source of dietary fiber that will help support healthy digestion. Tomato extract powder/lycopene is a natural pigment contained in plants such as tomatoes and is one of the strongest antioxidants found in nature.  It has been found to help dry eyes, dry coughs, mouth ulcers, etc.

Bilberry, also known as the European blueberry, whortleberry, or huckleberry, has a very high concentration of anthocyanins which are antioxidants. 

These antioxidant properties promotes healthy eye tissue, retina health, and structure for optimal vision.  It may also help manage inflammation of the retina and other ocular tissues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892183/

https://pubmed.ncbi.nlm.nih.gov/28617532/